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Therapeutic effects of ablative radiation on local tumor

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Radiotherapy-Induced Anti-Tumor Immunity Contributes to .

Purpose There is growing evidence that tumor-specific immune responses play an important role in anti-cancer therapy, including radiotherapy. Using mouse tumor models we demonstrate that irradiation-induced anti-tumor immunity is essential for the therapeutic efficacy of irradiation and can be augmented by modulation of cytotoxic T lymphocyte (CTL) activity.

The Role of Radiation Oncology in Immuno‐Oncolo

Despite the immune‐stimulating effects of local radiation, relapses often occur, and abscopal effects are rare, suggesting that radiation likely does not engage a sufficiently strong adaptive immune response to completely eliminate the tumor. Synergistic effects of various combinations have been observed on different models.

Locally Ablative Radiation Therapy of a Primary Human .

Methods and Materials. A total of 1 × 10 6 human small cell lung cancer cells (OH1, H69) were subcutaneously injected into severe combined immunodeficiency mice to form a local primary tumor node at the lower trunk. Radiation therapy, OP, RChT, or ChT were started after development of palpable tumors. Chemotherapy was given as a single intraperitoneal injection of cisplatin.

The Efficacy of Radiotherapy Relies upon Induction of Type .

The most widely held explanation for the efficacy of local radiotherapy (RT) is based on direct cytotoxicity to cancer cells through the induction of lethal DNA damage. Recent studies have shown that local ablative radiation of established tumors can lead to increased T-cell priming and T-cell–dependent tumor regression, but the underlying mechanism remains unclear.

Harnessing the Immunomodulatory Effects of Radiation .

Lugade AA, Moran JP, Gerber SA, et al. Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol. 2005;174:7516-23. 28. Hiniker SM, Chen DS, Reddy S, et al. A systemic complete response of metastatic melanoma to local radiation and immunotherapy.

Therapeutic effects of ablative radiation on local tumor .

Therapeutic effects of ablative radiation on local tumor require CD8 + T cells: changing strategies for cancer treatment. ... were CFSE labeled and then adoptively transferred into B16-SIY tumor-bearing mice that received a high dose of RT on local tumor.

Combining immunotherapy with radiation therapy to induce .

Ionizing radiation has been used for over a century to treat cancer. Historically, radiation was only thought to improve the local control of cancer. However, a growing body of evidence shows that radiation may induce a regression of tumor cells outside the field of irradiation, a phenomenon known as the abscopal effect.

Therapeutic effects of ablative radiation on local tumor .

TY - JOUR. T1 - Therapeutic effects of ablative radiation on local tumor require CD8 + T cells. T2 - Changing strategies for cancer treatment. AU - Lee, Youjin

Radiobiological basis of SBRT and SRS | SpringerLi

Lee Y, Auh SL, Wang Y et al (2009) Therapeutic effects of ablative radiation on local tumor require CD8 + T cells: changing strategies for cancer treatment. Blood 114:589–595 PubMedCentral PubMed CrossRef Google Scholar

Therapeutic effects of ablative radiation on local tumor .

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.

From DNA Damage to Nucleic Acid Sensing: A Strategy to .

Local irradiation (IR) is widely used in the treatment of primary and metastatic tumors. However, the impact of IR on the immune response is currently being defined. Local and distant relapse after radiotherapy often occurs. The current rationale for the use of IR is based on direct cytotoxicity to cancer cells; however, recent studies have shown that reduction of tumor burden following ...

Locally Ablative Radiation Therapy of a Primary Human .

Methods and Materials. A total of 1 × 10 6 human small cell lung cancer cells (OH1, H69) were subcutaneously injected into severe combined immunodeficiency mice to form a local primary tumor node at the lower trunk. Radiation therapy, OP, RChT, or ChT were started after development of palpable tumors. Chemotherapy was given as a single intraperitoneal injection of cisplatin.

Using immunotherapy to boost the abscopal effect | Nature .

Lee, Y. et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood 114 , 589–595 (2009). CAS

Abscopal Effects after Conventional and Stereotactic Lung .

Out-of-field (abscopal) tumor response is a manifestation of the systemic effect of radiation and has been documented in several tumor types.1 However, clinical reports of abscopal effects in non–small-cell lung carcinoma (NSCLC) are extremely rare.2 This report describes an instance of apparent spontaneous regression of metastases outside of irradiated portals in a patient with NSCLC ...

Immunotherapy and stereotactic ablative radiotherapy .

Therapeutic effects of ablative radiation on local ... Abscopal regression of antigen disparate tumors by antigen cascade after systemic tumor vaccination in combination with local tumor radiation.

Therapeutic effects of ablative radiation on local tumor .

Therapeutic effects of ablative radiation on local tumor require CD8+ T ... Local tumor irradiation and systemic chemotherapy Mice were irradiated using an x-ray generator (PCM 1000; Pantak) at the doses indicated by each experiment. Each mouse was protected with a lead

Therapeutic effects of ablative radiation on local tumor .

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment By Youjin Lee, Sogyong L. Auh, Yugang Wang, Byron Burnette, Yang Wang, Yuru Meng, Michael Beckett, Rohit Sharma, Robert Chin, Tony Tu, Ralph R. Weichselbaum and Yang-Xin Fu

Abscopal Effects after Conventional and Stereotactic Lung .

Out-of-field (abscopal) tumor response is a manifestation of the systemic effect of radiation and has been documented in several tumor types.1 However, clinical reports of abscopal effects in non–small-cell lung carcinoma (NSCLC) are extremely rare.2 This report describes an instance of apparent spontaneous regression of metastases outside of irradiated portals in a patient with NSCLC ...

Synergistic STING activation by PC7A nanovaccine and .

First, radiation can damage the tumor tissue and reorganize tumor-associated blood vessels, which presumably allows for better T cell or cytokine penetration [28,29]. Second, it has been shown that the therapeutic effect of ablative radiation therapy depends largely on CD8 + T cells, as radiation increases T cell priming .

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatme

Therapeutic effects of ablative radiation on local tumor require CD8 + T cells: changing strategies for cancer treatment Youjin Lee , Sogyong L. Auh , Yugang Wang , Byron Burnette , Yang Wang , Yuru Meng , Michael Beckett , Rohit Sharma , Robert Chin , Tony Tu , Ralph R. Weichselbaum and Yang-Xin Fu

Abscopal effects of radiation therapy: A clinical review .

In routine clinical practice, generalized fatigue, anorexia and weight loss are commonplace effects of localized therapeutic irradiation. A rarer clinical response to radiation therapy is tumor regression at sites distant to the irradiated volume, commonly known as the abscopal effect.